ABSTRACT
Background: Common carotid intima-media thickness [CC-IMT] measured by ultrasonography as a non-invasive method is nowadays known as a marker for early atherosclerosis
Objectives: Survey the relationship between serum uric acid and carotid intima-media thickness considering hypertension
Materials and Methods: This study was designed as a comparative cross-sectional study in northern Iran in 2013-2014. The samples for uric acid level were taken from 90 patients. Data were collected through questionnaires and a non-invasive ultrasound technique was used to measure IMT. The analysis of data was done by one-way ANOVA and Tukey post hoc tests and logistic regression model using SPSS software version 21. The significance level was set as 0.05
Results: Patients in the 3 groups were the same age and gender. The measured carotid intima-media thickness was significantly different among the groups [p=0.004]. Using multivariate logistic regression and entering all variables. The intima-media thickness of the carotid in the group with hypertensive and hyperuricemia was significantly higher than that of the other research groups [p<0.05]
Conclusion: An association was found between serum uric acid level and increased thickness of carotid intima-media and hyperuricemia can be considered as a risk factor for atherosclerosis
ABSTRACT
OBJETIVO:Um dos maiores problemas no uso da espirometria é a avaliação dos valores obtidos em comparação a valores de referência padronizados. Tais valores de referência devem ser determinados pelo estudo de populações semelhantes àquelas que se deseja utilizar. Considerando as diferenças antropométricas entre raças e o efeito de variáveis regionais, como clima e qualidade do ar, recomenda-se que esses padrões sejam definidos e utilizados regionalmente. O objetivo deste estudo foi medir os valores espirométricos em residentes da província de Mazandaran, no Irã; determinar quais valores de referência padronizados se correlacionam de forma mais próxima aos valores obtidos; e produzir equações preditivas para a população alvo. MÉTODOS: Estudo transversal com 1.499 voluntários, dos quais dados demográficos e antropométricos foram coletados. Após terem sido instruídos quanto ao procedimento adequado, cada voluntário foi submetido à espirometria, sendo obtidas três curvas espirométricas de acordo com os critérios de aceitabilidade da American Thoracic Society. O teste com os maiores valores de VEF1 e CVF foram utilizados na análise. RESULTADOS: Houve correlações significativas entre os valores medidos e os valores de referência em ambos os gêneros. As correlações mais fortes ocorreram com os valores de referência da European Respiratory Society e com a faixa etária de 18-20 anos. As equações preditivas produzidas basearam-se nos coeficientes de regressão obtidos e nos dados demográficos coletados. CONCLUSÕES: Nossos resultados mostram que os valores de referência da European Respiratory Society são os mais apropriados para a população estudada.
OBJECTIVE: One of the major issues in the use of spirometry is the evaluation of the values obtained in comparison with standardized reference values. Such reference values should be determined by studying populations similar to the population in which they are intended to be used. Considering the anthropometric differences among races and the effect of regional issues, such as climate and air quality, it is recommended that these standards be set and used regionally. The objective of this study was to measure the spirometric values in residents of the Mazandaran province in Iran, as well as to determine which standardized reference values most closely correlate with the values obtained and to devise predictive equations for the target population. METHODS: This was a cross-sectional study of 1,499 volunteers, from whom demographic and anthropometric data were collected. After having been instructed in the correct procedure, each volunteer underwent spirometry. From each volunteer, we obtained three spirometry curves that met the acceptability criteria established by the American Thoracic Society. The test with the highest values of FEV1 and FVC was employed in the analysis. RESULTS: We observed significant correlations between the measured values and the reference values, for both genders. The strongest correlations were with the European Respiratory Society reference values and with the 18-20 year age bracket. The predictive equations devised were based on the regression coefficients obtained and the demographic data collected. CONCLUSIONS: Our results show that the European Respiratory Society standard is the most appropriate standard for use in the population studied.